Fig 4.

Dominant core amino acid haplotypic sequences dependent on the core aa 70 residues are given for all 79 patients. Two dominant sequences (a dominant core sequence in isolates with aa 70R and a dominant core sequence in isolates with aa 70non-R) were included for each of nine patients with high mixture rates (5% or more) of R and non-R at core aa 70, while one dominant sequence each was included for other patients. Therefore, a total of 88 haplotypic sequences are shown here. Since most amino acid mutations were observed in the limited core region, only that part of the core sequence is shown. The HCV-J isolate is used as the reference sequence for the core region.