Table 5.

Comparison of genetic distances among core subgroups related to aa 70 residues

Patient(s)a	Genetic distance (mean ± SD) between two core sequencesb			Comparison of genetic distance measurements
	Non-R–non-R	Non-R–R	R-R	Non-R–R vs non-R–non-R		Non-R–R vs R-R		Non-R–non-R vs R-R
				Larger genetic distance	P	Larger genetic distance	P	Larger genetic distance	P
All (n = 79)	0.0349 ± 0.0101	0.0379 ± 0.0109	0.0401 ± 0.0113	Non-R–R	<0.001	R-R	<0.001	R-R	<0.001
CH
Pt 1	0.0086 ± 0.0042	0.0098 ± 0.0037	0.0064 ± 0.0042	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	<0.001
Pt 2	0.0097 ± 0.0048	0.0104 ± 0.0041	0.0087 ± 0.0038	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	0.009
Pt 3	0.0107 ± 0.0058	0.0137 ± 0.0050	0.0034 ± 0.0022	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	<0.001
LC
Pt 4	0.0078 ± 0.0036	0.0103 ± 0.0038	0.0053 ± 0.0029	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	<0.001
Pt 5	0.0118 ± 0.0090	0.0232 ± 0.0085	0.0159 ± 0.0170	Non-R–R	<0.001	Non-R–R	<0.001	No difference	0.991
Pt 6	0.0115 ± 0.0057	0.0121 ± 0.0055	0.0108 ± 0.0056	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	<0.001
Pt 7	0.0141 ± 0.0085	0.0146 ± 0.0070	0.0136 ± 0.0067	Non-R–R	0.002	Non-R–R	<0.001	Non-R–non-R	<0.001
HCC
Pt 8	0.0124 ± 0.0063	0.0225 ± 0.0060	0.0181 ± 0.0094	Non-R–R	<0.001	Non-R–R	<0.001	R-R	<0.001
Pt 9	0.0082 ± 0.0042	0.0162 ± 0.0047	0.0078 ± 0.0050	Non-R–R	<0.001	Non-R–R	<0.001	Non-R–non-R	<0.001

^aPt, patient.

^bNon-R–non-R, comparison of two core sequences with residues other than R at aa 70; Non-R–R, comparison of a core sequence with a residue other than R at aa 70 and a core sequence with aa 70R; R-R, comparison of two core sequences with aa 70R. Genetic distances were calculated for all patients by using dominant sequences and for a single patient by using quasispecies sequences.