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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Am Chem Soc. 2013 Aug 6;135(32):10.1021/ja4046795. doi: 10.1021/ja4046795

Figure 7.

Figure 7

Functional blockade of hKv1.3 currents by L- and D- ShK synthetic toxins using the cut-open oocyte voltage clamp method15 to measure potassium ionic currents from Xenopus laevis oocytes that contained expressed human Kv1.3 (hKv1.3) channels. Peak currents were recorded during a 150ms step to + 30 mV from a holding voltage of −90 mV (upper inset). The fractions of current blockade are plotted for test concentration of L-ShK (filled squares, n = 3–5 cells) and D-ShK (open squares, n = 3–6 cells). Dotted lines indicate dose-response curves fitted by the Hill equation. Error bars in figure and uncertainties in table indicate standard error of the mean.