Fig 6.
NSC95397 limits the pathogenesis of influenza A/WSN/33 virus infection in vivo. BALB/c female mice were infected with a lethal dose (103 PFU) (A and B) or a sublethal dose (70 PFU) (C) of influenza A/WSN/33 virus and treated with DMSO or 2.5 mg/kg NSC95397 orally at 24 h pre- or postinfection. Mouse survival (A) and weight loss (B) were monitored daily for 14 days according to guidelines from the IACUC of the University of Georgia. (C) RNA was isolated from lungs of infected mice at 72 hpi, and virus copy numbers were evaluated by qRT-PCR. *, P < 0.05; **, P < 0.01; ***, P < 0.001.