Fig 2.

CoPP attenuates EBOV growth in Vero VP30 and Huh 7.0 VP30 cells. (A and B) Growth kinetics (FFU/ml) of EbolaΔVP30 virus in Vero VP30 cells (A) and Huh 7.0 VP30 cells (B) after treatment with the indicated concentrations of CoPP 8 h prior to infection (pretreatment) or immediately following infection (posttreatment) with EbolaΔVP30 virus at an MOI of 0.001. All values for CoPP-treated cells (pre- and postinfection) are statistically significant (P ≤ 0.05) compared to the values for vehicle-treated cells on the same day, except the 10 μM posttreatment in Vero VP30 cells on day 3 at an MOI of 0.001. (C) Growth kinetics of EbolaΔVP30 in Vero VP30 cells following direct incubation with vehicle or 15 μM CoPP for 1 h. The data are presented as means ± SD (for small SD, the error bars may not be clearly visible) and are representative of at least three independent experiments.