Fig 5.

The competitive HO-1 inhibitor SnPP does not attenuate EBOV growth. (A) Western blot demonstrating the induction of HO-1 in Vero VP30, Huh 7.0 VP30, and 293T cells by the selective HO-1 enzymatic inhibitor SnPP. (B) Growth of EbolaΔVP30 virus in Vero VP30 or Huh 7.0 VP30 cells 5 days posttreatment with CoPP or SnPP (10 μM in Vero VP30 and 15 μM in Huh 7.0 VP30 cells) and infection at an MOI of 0.01. All data are presented as means and SD and are representative of at least three independent experiments. The asterisks indicate statistical significance compared to the control (P ≤ 0.05).