Fig 7.

HO-1 expression attenuates EBOV transcription/replication. (A) Relative polymerase activity (compared to vehicle-treated cells) from an EBOV minireplicon assay in 293T cells after treatment with 10 μM CoPP or SnPP for 2 days. (B) Relative polymerase activity (compared to empty vector) from an EBOV minireplicon assay in 293T cells that were transfected with a HO-1 overexpression plasmid for 2 days. (C) Relative polymerase activity (compared to HEK 293 VP30 cells) 2 days posttransfection with EBOV minireplicon plasmids in HEK 293 VP30/HO-1 cells. The data are presented as means ± SD and are representative of at least three independent experiments. The asterisks indicate statistical significance compared to the control (P ≤ 0.05).