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. 2013 Dec;87(24):13816–13824. doi: 10.1128/JVI.02515-13

Fig 1.

Fig 1

The extent of CpG depletion is closely linked to host methylation capabilities. (a) Box plot showing CpG O/E ratios in parvoviruses infecting different classes of host species; all autonomous parvovirus sequences studied were analyzed (n = 259). Parvoviruses infecting invertebrates have significantly higher CpG O/E ratios than parvoviruses infecting vertebrates (P < 0.0001). (b) Box plot showing the CpG O/E ratios in parvoviruses infecting different classes of host species in a subset of sequences (one sequence each for every autonomous parvovirus; n = 56) (P < 0.0001). (c) CpG depletion is more pronounced among parvoviruses infecting mammals than among those infecting crustaceans and insects when analyzing all the sequences studied (n = 259) (mammals compared to crustaceans, mean ± SD, 0.50 ± 0.15 compared to 0.62 ± 0.11, P = 0.01; mammals compared to insects, mean ± SD, 0.50 ± 0.15 compared to 0.82 ± 0.18, P < 0.0001). (d) CpG depletion is more pronounced among parvoviruses infecting mammals compared to those infecting crustaceans and insects in the subset of sequences analyzed (n = 56) (mammals compared to crustaceans, mean ± SD, 0.44 ± 0.17 compared to 0.63 ± 0.12, P = 0.03; mammals compared to insects, mean ± SD, 0.44 ± 0.17 compared to 0.84 ± 0.19, P < 0.0001).