Fig 2.

Relation between herpesvirus carriage and functional capacity of NK cells. PBMC from CMV⁻ (n = 12) and CMV⁺ (n = 21) children were rested for 20 h, followed by culture during 4 h in medium alone or with K562 target cells. Subsequently, viable, CD14⁻ CD19⁻ CD3⁻ CD56^dim lymphocytes were analyzed for the proportions of CD107a (A and B), IFN-γ (C), TNF (D), and MIP-1β (E) cell positivity by flow cytometry. (B) Proportions of CD107a⁺ CD56^dim NK cells upon stratification of CMV⁻ and CMV⁺ groups based on EBV serostatus. Filled circles and crosses depict outlier and extreme values, respectively. Functional assay values, where from statistical data were acquired, correspond to values from nonstimulated cultures subtracted from stimulated cultures.