Fig 3.

Comparison of the KSHV ORF K1 and the RFHVMn ORF RF1 protein sequences. The sequences of KSHV ORF K1 (YP_001129350) and the RFHVMn ORF RF1 (AGY30683) positional homolog were aligned. Identical residues are highlighted in black. The regions conserved with the immunoglobulin (Ig) superfamily and the immunoglobulin receptor tyrosine–based activation motif (ITAM) are indicated, and the variable regions (VR1 and VR2) identified in the KSHV subtypes (45) are shown. The residues predicted to form a hydrophobic transmembrane (TM) domain and the positions of two repeat domains present in the RF1 sequence are indicated. Potential N-linked glycosylation sites are underlined, and sites conserved between K1 and RF1 are indicated with asterisks. Dashed lines represent gaps in the sequence, while solid lines represent continuations of the left and right brackets.