Fig 5.

Comparison of the KSHV ORF K7 and RFHV ORF RF7 protein sequences. The sequences of KSHV ORF K7 (YP_001129367) and the RFHVMn ORF RF7 (AGY30697) positional homolog were aligned. Since the K7 sequence was previously shown to have sequence similarity to human survivin, the sequence of survivin/baculoviral IAP repeat containing protein 5 isoform 2 (NP_001012270) from aa 7 to aa 94 was aligned to the RF7 and K7 sequences. Amino acid residues conserved among all three sequences are highlighted in black, those conserved between RF7 and K7 are highlighted in green, those conserved between RF7 and survivin are highlighted in red, and those conserved between K7 and survivin are highlighted in blue. Putative N-terminal hydrophobic transmembrane domains are underlined.