Fig 6.

Phylogenetic analysis of the vIRF homologs. The encoded amino acid sequences of the vIRF homologs of KSHV (K9 [YP_001129411], K10 [YP_001129414], K10.5 [YP_001129413], and K11 [YP_001129412]), RFHVMn (RF9-11 [AGY30740-43; this study]), and RRV (R9.1 [AAF60036], R9.2 [AAF60037], R9.3 [AAF60038], R9.4 [AAF60039], R9.5 [AAF60040], R9.6 [AAF60041], R9.7 [AAF60042], and R9.8 [AAF60043]) were aligned using MUSCLE, and phylogeny was determined by protein maximum likelihood. The human (NP_002154) and rhesus macaque (NP_001252887) cellular interferon regulatory factor 8 sequences were used as an outgroup. The lineage divisions of the RV1 and RV2 rhadinovirus proteins and the cellular proteins are indicated with dashed lines, and the presence of spliced transcripts is noted. The numbers of substitutions per site are indicated.