Skip to main content
. Author manuscript; available in PMC: 2013 Nov 22.
Published in final edited form as: Stroke. 2012 Feb 16;43(3):10.1161/STROKEAHA.111.632935. doi: 10.1161/STROKEAHA.111.632935

Table 4.

Performance of the dichotomous analysis (dichotomized at 0-1 versus 2-6), the Cochran-Mantel-Haenszel (CMH) test, proportional odds model (POM), and proposed model. For dichotomous analyses: A =active treatment (investigational treatment), P=placebo. For the proportional odds model: the test of proportional odds is the probability that the assumption of proportional odds is met in the study

Dichotomous
Outcome		 Ordinal outcome Approach
%
mRS
Score
of 0/1		 Treatme
nt p-
value		 CMH
Test		 Proportional Odds Test Proposed Approach (with Permutation/Randomization
Test)
CMH
P-
Value		 Test of
Proportion
al Odds
Assumptio
n		 Treatme
nt
Differen
ce P-
value		 Odds Ratio
(95% CI)		 Proporti
on Better		 Proporti
on
Worse		 Proporti
on Same		 Proportio
n of
changes
better for
active
treatment		 Treatme
nt
Differen
ce p-
value
tPA3, 17
(n = 619)		 A:
33%
P:
17%		 <0.0001 <0.000
1		 0.14 0.0002 1.69
(1.28 -
2.25)		 48.0% 31.5% 20.5% 60.4% 0.0001
SAINT
112
(n =
1,699)		 A:
33%
P:
31%		 0.28 0.138 0.059 0.153 1.13
(0.96 -
1.34)		 43.1% 39.2% 17.7% 52.4% 0.151
Alias 17
(n = 257)		 A:
28%
P:
37%		 0.16 0.654 0.43 0.625 1.11
(0.72 -
1.71)		 43.4% 40.0% 16.6% 52.1% 0.626
Minocycl
ine
Trial20
(n = 151)		 A:
80%
P:
25%		 <0.0001 <0.000
1		 0.78 <0.0001 13.16
(6.54 -
27.03)		 76.7% 9.4% 13.9% 89.1% <0.0001