Table 1. Pregnancy and birth characteristics for the sGC cases a (n=37) and matched controls (n=185); 1:5 matching ratio, matched on logit of propensity score.
| Characteristic |
Mean ± SD or n (%)
|
||
|---|---|---|---|
| Case | Control | P | |
| Pregnancy | |||
| Maternal age (years) | 29.2 ± 5.0 | 27.6 ± 5.2 | .10 |
| Family structure | .37 | ||
| Married/co-habiting | 36 (97.3) | 173 (93.5) | |
| Single/widowed/divorced | 1 (2.7) | 12 (6.5) | |
| Education (years) | .92 | ||
| <11 | 10 (31.3) | 54 (32.1) | |
| ≥11 | 22 (68.8) | 114 (67.9) | |
| Parity | .98 | ||
| 0 | 11 (29.7) | 60 (32.4) | |
| 1 | 16 (43.2) | 76 (41.1) | |
| 2 | 6 (16.2) | 32 (17.3) | |
| ≥ 3 | 4 (10.8) | 17 (9.2) | |
| Smoking during pregnancy | .17 | ||
| No | 31 (86.1) | 137 (75.7) | |
| Yes | 5 (13.9) | 44 (24.3) | |
| Pre-pregnancy BMI | 21.1 ± 2.5 | 20.5 ± 2.6 | .22 |
| Pre-pregnancy BMI categories | .44 | ||
| < 20 | 14 (37.8) | 87 (47.0) | |
| 20-24.99 | 20 (54.1) | 90 (48.6) | |
| ≥ 25 | 3 (8.1) | 8 (4.3) | |
| Main pregnancy complications – risk for pre-term birth | |||
| Gestational hypertension | 0 (.0) | 13 (7.1) | .23 |
| Pre-eclampsia | 1 (5.3) | 4 (2.2) | .41 |
| Placenta previa | 0 (.0) | 1 (.5) | .65 |
| Total sGC dose (mg) | 15.4 ± 4.6 | ||
| Interval between prenatal sGC exposure and birth (days) | |||
| 6-14 | 5 (13.5) | ||
| 15-23 | 0 (.0) | ||
| 24-32 | 6 (16.2) | ||
| 33-41 | 8 (21.6) | ||
| 41-49 | 10 (27.0) | ||
| 50-58 | 4 (10.8) | ||
| 59-67 | 2 (5.4) | ||
| ≥ 68 | 2 (5.4) | ||
| Birth | |||
| Sex | .86 | ||
| Male | 19 (51.4) | 98 (53.0) | |
| Female | 18 (48.6) | 87 (47.0) | |
| Gestational age at birth (weeks) | 37.2 ± 2.0 | 37.5 ± 2.0 | .60 |
| Gestational age categories (weeks) | .90 | ||
| Pre-term birth (< 37) | 10 (27.0) | 48 (25.9) | |
| Term birth (≥ 37) | 27 (73.0) | 137 (74.1) | |
| Birthweight (g) | 3159 ± 688 | 3151 ± 636 | .95 |
| Birthweight categories (g) | .59 | ||
| < 2500 | 6 (16.2) | 23 (12.4) | |
| 2500-4499 | 30 (81.1) | 160 (86.5) | |
| ≥ 4500 | 1 (2.7) | 2 (1.1) | |
| Placental weight (g) | 586 ± 139 | 588 ± 135 | .96 |
| Placental weight categories (g) | .90 | ||
| < 550 | 14 (37.8) | 75 (40.8) | |
| 550-719 | 17 (45.9) | 84 (45.7) | |
| ≥ 720 | 6 (16.2) | 25 (13.6) | |
a
Including cases exposed to prenatal sGC > 4 days prior to birth.