Table 2. Linear multiple regression results for the association between prenatal glucocorticoid treatment (cases a , n=37 (at 8y) n=29 (at 16y), and controls balanced on gestational age and pre-pregnancy BMI, by means of logit of propensity score; 1:5 matching ratio) and mental health outcome scores for children and adolescents, adjusted for relevant confounders b .
| Mental Health |
Prenatal glucocorticoid (GC) treatment (case/control)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Unadjusted
|
Adjusted
b
|
||||||||
| B | 95% CI for B | β | P | B | 95% CI for B | β | P | Cohen’s f2 | |
| 8-y-olds Rutter (teacher report) | |||||||||
| Total Rutter score | 1.07 | -.95-3.10 | .08 | .30 | 8.34 | .23-16.45 | .56 | .04 | .23 |
| Antisocial score | .28 | -.45-1.00 | .05 | .45 | 2.93 | -.04-5.9 | .54 | .05 | .20 |
| Neurotic score | .11 | -.39-.62 | .03 | .66 | 1.55 | -.55-3.67 | .42 | .15 | .11 |
| Inattention-hyperactivity score | .21 | -.40-.72 | .04 | .58 | 2.16 | -.03-4.35 | .52 | .05 | .33 |
| Inattention score c | -.02 | -.23-.18 | -.02 | .81 | .97 | .16-1.80 | .64 | .02 | .23 |
| Hyperactivity score d | .19 | -.21-.58 | .07 | .35 | 1.19 | -.29-2.67 | .41 | .12 | .36 |
| 16-y-olds SWAN (parent report) | |||||||||
| Combined ADHD score | -1.15 | -8.48-6.19 | -.03 | .76 | 16.20 | -14.65-47.04 | .34 | .30 | .11 |
| Inattention score e | -.53 | -4.31-3.24 | -.02 | .78 | 9.00 | -6.42-24.41 | .37 | .25 | .11 |
| Hyperactivity score f | -.61 | -4.60-3.38 | -.02 | .76 | 7.20 | -9.85-24.26 | .27 | .41 | .10 |
| 16-y-olds YSR (self-report) | |||||||||
| YSR Total Problem score | 2.10 | -4.55-8.74 | .05 | .53 | 2.30 | -26.43-31.00 | .05 | .88 | .12 |
a
Including cases exposed to prenatal sGC > 4 days prior to birth.
b
adjusted for sex, birthweight, placental weight, socio-demographic factors (maternal age, education and family structure), and medical factors (total prenatal sGC dose, interval between prenatal sGC exposure and birth (days), smoking during pregnancy and parity).
c
score based on Rutter item number 16 (range 0 to 2).
d
score based on sum of Rutter items 1 and 3 (range 0 to 4).
e
score based on sum of 9 SWAN items (range -27 to 27).
f
score based on sum of 9 SWAN items (range -27 to 27).