Figure 8. Determination of tumor size in nude mice.
(A) Treatment of nude mice bearing human breast cancer xenografts with BT-474. Injection of BT-474 breast carcinoma cells to the nude mice resulted in the growth of xenografts. The Tumors were injected 3 times a week with 109 PFU of recombinant NBPs, only vector and PBS. Hereafter, tumor growth was measured regularly, (B) Volumes of the BT-474 tumor tissue during treatment. Median tumor volume is determined over time in all treated groups. Tumor volumes were calculated using the equation: Length × width2 ×0.52, (C) The effects of different treatments on change in body weight over the treatment period. Average body weight was calculated for each treatment group at the indicated time points.