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. 2013 Nov 22;8(11):e81523. doi: 10.1371/journal.pone.0081523

Figure 1. Pyruvate reduces R/M hypoglycemia-induced cortical neuronal death in diabetic rats.

Figure 1

(A, C) Fluorescence images show degenerating neurons stained green by Fluoro-Jade B in the parietal (PT Ctx) and perirhinal (PRh Ctx) cortex region at three days after R/M hypoglycemia with or without pyruvate. Pyruvate administered into the intraperitoneal space as an adjuvant to glucose at ten minutes after R/M hypoglycemia and provided protective effects on cortical neuronal death compared to vehicle (glucose only)-treated rats. Scale bar = 100 μm. (B, D) Bar graphs show number of degenerating neurons in five vulnerable brain regions. Data are means ± s.e.m., n=5-6 from each group, *P<0.05.