Figure 8.

Global maximum weight paths using three different graph representations for helix unfolding under 0pN stress. Bottleneck edges (EMW) are in red. Note that the second path, represented in anchor space, has a loop to from alpha3 to alpha2. Directional Milestoning representation allows for such choices since entry milestones (interfaces) can be different for the same state. The source of the difference between the state-based and flux-based graph is the finer (more detailed) description of the system in the flux-based graph. (a) OpN, Path from state-space graph based on flux-based edge weights; (b) OpN, Path from flux-space graph based on flux-based edge wights; (c) OpN, Path from flux-space graph based on rate coefficients.