Figure 1. CS limits macrophage ability to control intracellular bacterial growth.

THP-1 (A) and MDM (B) macrophages were exposed to CS at concentrations of 1, 5 and 10 μg/ml for 24 h and then infected with Mtb-H37Rv (MOI 1). On day 4 post-infection, CFU were enumerated. Bars indicate mean ± SD from five independent experiments. *P<0.05, **P<0.01. ANOVA and Dunnett’s post-hoc test compared to unexposed macrophages.