Table 2.

Breast Density Reduction at 4 weeks’ and 12 weeks’ Treatment

Measure	Time	Geometric mean (interquartile range)	P-value for comparison to baseline*	Percent reduction from baseline (mean ± SD)
FV (ml)	Baseline	110 (67.2, 189.8)
	4 weeks	104.3 (66.6, 164.4)	p<0.0001	4.3 ± 12.7
	12 weeks	94.7 (60.2, 144.4)	p<0.0001	12.2 ± 15.6
PD (%)	Baseline	11.2 (6.4, 22.4)
	4 weeks	10.6 (6.6, 20.3)	p<0.0001	4.1 ± 13.8
	12 weeks	9.7 (6.2, 17.9)	p<0.0001	11.1 ± 19.1

^*Paired t-test for comparison of mean difference in log_e(FV) measured at 4 weeks versus 12 weeks (p=0.016) and in log_e(PD) (p=0.018).