Table 1.
Frequency of metastases at various anatomical sites.
| Models | Orthotopic | Intra‐cardiac | ||||
|---|---|---|---|---|---|---|
| PC3 cells | EV | SPARCL1 | P value | EV | SPARCL1 | P value |
| Visceral sites | ||||||
| Liver | 80(8/10)a | 63(5/8) | 90(9/10) | 75(6/8) | ||
| Pancreases | 60(6/10) | 25(2/8) | 67(6/9) | 25(2/8) | ||
| Spleen | 38(3/8) | 38(3/8) | 44(4/9) | 13(1/8) | ||
| Adrenal glands | 90(9/10) | 50(4/8) | 80(8/10) | 13(1/8) | ||
| Kidney | 100(10/10) | 63(5/8) | 80(8/10) | 13(1/8) | ||
| Total metastasis | 75(36/48) | 48(19/40) | 0.01 | 73(35/48) | 28(11/40) | <0.001 |
| Skeletal sites | ||||||
| Tibia | NAb | NA | 40(8/20) | 13(2/16) | ||
| Femur | NA | NA | 30(6/20) | 19(3/16) | ||
| Mandible | NA | NA | 70(7/10) | 38(3/8) | ||
| Iliac crest | NA | NA | 5(1/20) | 6(1/16) | ||
| Ankle/paw | NA | NA | 3(1/40) | 0(0/32) | ||
| Humerus shoulder | NA | NA | 15(3/20) | 13(2/16) | ||
| Total metastases | NA | NA | 20(26/130) | 11(11/104) | 0.07 | |
P value was computed by Fisher exact test.
percentage (numbers of organs with metastasis/total organs inspected).
NA: data not available.