Table I.
MMR mutation, carrier status, perceived risk estimates, predicted risk (MMRpro), gender, age, reported screening history and medical screening advice.
| ID | MMR Gene mutate d in the family | Carrier status1 | Risk Estimate | Perce ived Risk: | Gender | Age at | Reported Screening Colonoscopy History (Years) | ||
|---|---|---|---|---|---|---|---|---|---|
| Percei ved | Predic ted (MMR pro) | Predi cted Risk | Inter view | Last Screened | Advised Interval between Screens | ||||
| D18 | MSH2 | Non-carrier | 1 | 1.1 | 0.91 | M | 58 | 2 | 4 |
| D10 | MLH1 | Carrier | 20 | 15.2 | 1.32 | F | 42 | 3 | 1 |
| D6 | MLH1 | Carrier | 40 | 29.4 | 1.36 | M | 44 | 2 | 5 |
| D14 | MSH2 | Carrier | 20 | 10 | 2.00 | M | 32 | Never | Start After 30yo |
| D1 | MSH6 | Non-carrier | 4 | 1.7 | 2.35 | M | 65 | 10 | No Medical Advice |
| D26 | PMS2 | Untested, daughter of carrier | 10 | 3.2 | 3.13 | F | 32 | Never | Not Required Yet |
| D17 | MLH1 | Non-carrier | 3 | 0.6 | 5.00 | M | 50 | 0.52 | 5 |
| D25 | MSH2 | Non-carrier | 4 | 0.8 | 5.00 | F | 30 | 2 | No Medical Advice |
| D5 | MLH1 | Carrier | 50 | 8.9 | 5.62 | F | 55 | Never | No Medical Advice |
| D23 | MSH2 | Untested, brother of carrier | 40 | 6.6 | 6.06 | M | 34 | 4 | 5 |
| D16 | MSH2 | Carrier | 20 | 3 | 6.67 | F | 27 | Never | No Medical Advice |
| D21 | MLH1 | Carrier | 60 | 8.6 | 6.98 | M | 31 | Never | Start After 35yo |
| D12 | MSH2 | Non-carrier | 5 | 0.7 | 7.14 | F | 54 | 0.12 | 3 |
| D22 | MLH1 | Carrier | 40 | 5.1 | 7.84 | M | 28 | 2 | 2 |
| D13 | MSH2 | Untested, daughter of carrier | 40 | 3.5 | 11.43 | F | 33 | Never | No Medical Advice |
| D8 | MLH1 | Non-carrier | 5 | 0.3 | 16.67 | M | 45 | 3 | 5 |
| D9 | MSH2 | Non-carrier | 20 | 1 | 20.00 | F | 51 | 0.12 | 2 |
| D4 | MSH2 | Non-carrier | 30 | 1.4 | 21.43 | F | 68 | 3 | 3 |
| D15 | MLH1 | Non-carrier | 5 | 0.1 | 50.00 | F | 29 | 1 | 5 |
| D7 | MLH1 | Non-carrier | 25 | 0.4 | 62.50 | M | 47 | 1 | 5 |
| D11 | MSH6 | Non-carrier | 76 | 1.1 | 69.09 | M | 58 | 4 | 2 |
| D24 | MSH2 | Non-carrier | 25 | 0.3 | 83.33 | F | 26 | Never | Start After 30yo |
| D2 | MLH1 | Non-carrier | 70 | 0.6 | 116.6 7 | F | 54 | 10 | 1 |
| D19 | MLH1 | Non-carrier | 80 | 0.6 | 133.3 3 | F | 53 | 2 | 2 |
| D3 | MSH2 | Non-carrier | 50 | 0.3 | 166.6 7 | M | 44 | 1 | 2 |
| D20 | MLH1 | Non-carrier | 50 | 0.1 | 500.0 0 | F | 30 | 1.5 | 2 |
| Means | 31 | 4.0 | 50.48 | – | 43 | – | – | ||
1
As determined by ACCFR protocol 3 0.5 = < 1 year; 0.1 = <1 month