TABLE 4.
Respiratory and Other Short-Term Morbidities
| Parameter | LOX (n = 44) | HOX (n = 44) | P |
|---|---|---|---|
| Respiratory morbidities | |||
| Respiratory distress syndrome | 28 (64) | 25 (57) | NS |
| Received surfactant | 15 (34) | 17 (39) | NS |
| Pneumothorax | 2 (4) | 2 (4) | NS |
| Pulmonary interstitial emphysema | 2 (4) | 5 (11) | NS |
| Pulmonary arterial hypertension | 1 (2) | 3 (7) | NS |
| Pneumomediastinum | 2 (4) | 0 (0) | NS |
| Pulmonary hemorrhage | 2 (4) | 6 (14) | NS |
| BPD | |||
| O2 at 28 d | 8 (19) | 17 (39) | .04 |
| O2 at 36 wk | 3 (7) | 11 (25) | .04 |
| Physiologic definitiona | 2 (4) | 10 (23) | .03 |
| Intravenous steroids for BPD | 1 (2) | 2 (4) | NS |
| HFOV | 2 (4) | 10 (23) | .03 |
| Days on mechanical ventilationb | 3 (0–64) | 8 (0–96) | .045 |
| Days on CPAPb | 4 (0–44) | 6 (0–43) | NS |
| Days on oxygenb | 4 (0–113) | 10 (0–163) | NS |
| Maximum Fio2b | 64 (25–100) | 100 (26–100) | NS |
| Other short-term morbidities | |||
| Sepsis proven | 8 (18) | 10 (23) | NS |
| IVH grade 3 or 4 | 1 (2) | 1 (2) | NS |
| Cystic PVL | 0 (0) | 1 (2) | NS |
| Necrotizing enterocolitis | 1 (2) | 6 (14) | NS |
| Symptomatic patent ductus arteriosus | 6 (14) | 10 (23) | NS |
| Severe ROP/need for laser therapy | 1 (2) | 4 (9) | NS |
| Days of hospitalizationb | 33 (7–126) | 40 (8–166) | NS |
| Death during initial hospitalization | 2 (4) | 3 (7) | NS |
NS, not significant.
a
The physiologic definition of BPD includes, as a criterion, the receipt of >30% O2 or the need for positive pressure support at 36 weeks or, in the case of infants requiring <30% O2, the need for any O2 at 36 weeks after an attempt at O2 withdrawal.
b
Median (range).