Table 2.
Extent of Liraglutide Protein Binding in Plasma Collected from Healthy Volunteers
| Mean (SD) Liraglutide Bound [%] | |||||
|---|---|---|---|---|---|
| Liraglutide Concentration of the Plasma Incubation Buffer (pM) | Male 1 | Male 2 | Female 1 | Female 2 | |
| Inner–outer ratio (100:1) | |||||
| 106 | 99.0 (0.5) | 98.6 (0.3) | 99.0 (0.2) | 98.3 (0.4) | |
| 104 | 99.2 (0.5) | 99.2 (0.5) | 99.1 (0.3) | 98.7 (0.6) | |
| 102 | 99.3 (0.3) | 99.0 (0.5) | 99.3 (0.5) | 98.8 (0.4) | |
| Inner–outer ratio (50:1) | |||||
| 106 | 98.4 (0.9) | 97.6 (0.5) | 98.6 (0.3) | 97.3 (0.3) | |
| 104 | 99.4 (0.1) | 98.2 (0.2) | 98.9 (0.8) | 97.0 (0.8) | |
| 102 | 99.2 (0.2) | 99.1 (0.2) | 99.2 (0.1) | 97.9 (1.0) | |
Data are unadjusted means (SD)