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. Author manuscript; available in PMC: 2014 Oct 22.
Published in final edited form as: Biochemistry. 2013 Oct 8;52(42):10.1021/bi401117y. doi: 10.1021/bi401117y

Figure 6.

Figure 6

An image that superimposes the partial X-ray crystal structure of ScOMPDC complexed with BMP (PDB entry 1DQX) over the structure for unliganded ScOMPDC (PDB entry 1DQW). The movement of the phosphodianion gripper loop (Pro202 to Val220) towards the hydrophobic pyrimidine umbrella (Ala151 – Thr165) is shown for the unliganded (orange) and liganded (olive green) enzymes. The closure of these loops is proposed to be cooperative, and driven by the formation of a hydrogen bond between the side chains of Gln215 from “gripper” loop and of Ser 154 from the “umbrella”.