TABLE 1D. Novel Loci Primarily Associated with Triglycerides Obtained from Joint GWAS and Metabochip Meta-analysis.
| Locus | MarkerName | Chr | hg19 Position (Mb) |
Associated trait(s) |
MAF | Minor/major Allele |
Effect of A1 | Joint N (in 1000s) |
Joint P-value |
|---|---|---|---|---|---|---|---|---|---|
| LRPAP1 | rs6831256 | 4 | 3.47 | TG, TCf,LDLf | .42 | G/A | 0.026/−0.022/− | 177/173/187 | 2×10−12/1×10−10/2×10−8 |
| 0.025 | |||||||||
| VEGFA | rs998584 | 6 | 43.76 | TG, HDL | .49 | A/C | 0.029/−0.026 | 175/184 | 3×10−15/2×10−11 |
| MET | rs38855 | 7 | 116.36 | TG | .47 | G/A | −0.019 | 178 | 2×10−8 |
| AKR1C4 | rs1832007 | 10 | 5.25 | TG | .18 | G/A | −0.033 | 178 | 2×10−12 |
| PDXDC1 | rs3198697 | 16 | 15.13 | TG | .43 | T/C | −0.020 | 176 | 2×10−8 |
| MPP3 | rs8077889 | 17 | 41.88 | TG | .22 | C/A | 0.025 | 176 | 1×10−8 |
| INSR | rs7248104 | 19 | 7.22 | TG | .42 | A/G | −0.022 | 176 | 5×10−10 |
| PEPD | rs731839 | 19 | 33.90 | TG, HDL | .35 | G/A | 0.022/−0.022 | 176/185 | 3×10−9/3×10−9 |
Chr, chromosome;MAF, minor allele frequency; A1, minor allele; A2, major allele.Effect sizes are given with respect to the minor allele (A1) in SD units. For loci associated with two or more traits at genome-wide significance, the trait corresponding to the strongest P-value is listed first. At one locus, secondary traits were most strongly associated with a different SNP:
f
rs6818397 (within 1 Mb of rs6831256, r2 = 0.18).