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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Neuropharmacology. 2013 Mar 28;71:10.1016/j.neuropharm.2013.03.013. doi: 10.1016/j.neuropharm.2013.03.013

Figure 2.

Figure 2

The secretion of ACTH (pg/ml; panel A) and corticosterone (CORT; ng/ml; panel B) on resting conditions (0 min) and after acute restraint stress (10, 30, 60 or 120 min) in rats previously submitted to daily 20 sec tail-lifting and home cage control conditions (CTRL) or chronic restraint stress (CRS; 20 min/day) for 14 days. On day 15, animals from both groups received an i.p. injection of vehicle (VEH; 1 ml/kg) or the 5-HT7 receptor antagonist, SB-656104 (SB; 1 mg/kg) 60 min before decapitation (0 min) or exposure to acute restraint stress sessions. Bars represent the mean and vertical lines denote the standard error of the mean of 6 observations. +++ P < 0.001 vs baseline (0 min); ++ P < 0.01 vs baseline (0 min); äää P < 0.001 vs baseline (0 min); *** P < 0.001.