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. 2013 Nov 14;170(7):1384–1395. doi: 10.1111/bph.12328

Figure 1.

Figure 1

Angiotensin II type 1a receptor knockout (AT1a-KO) and wild-type (WT) mice develop left ventricular hypertrophy to a similar degree after transverse aortic constriction (TAC). Left ventricular (LV) end-diastolic dimension (LVDd) (A), left ventricular posterior wall ( LVPW) thickness (B) and percent fractional shortening (%FS) (C) evaluated by echocardiography before and after TAC or sham operation. Values are means ± SEM. *P < 0.01 versus before each operation. (D) Heart weight-to-body weight (HW/BW) ratios 4 weeks after the operation. Values are means ± SEM. *P < 0.01 versus sham-operated mice in each genotype. WT-Sham, wild-type mice subjected to sham operation (n = 37); KO-Sham, AT1aR-KO mice subjected to sham operation (n = 38); WT-TAC, wild-type mice subjected to TAC (n = 45); KO-TAC, AT1aR-KO mice subjected to TAC (n = 35).