Figure 2.

Effects of chronic pressure overload on left ventricular expression of hypertrophic marker genes 4 weeks after transverse aortic constriction (TAC) or sham operation. Relative expression levels of ANP (A), BNP (B), Acta1 (C) and SERCA2 (D) mRNA were normalized to the corresponding GAPDH mRNA levels. The mean relative level of each mRNA in sham-operated wild-type (WT) mice was assigned a value of 1.0. Values are means ± SEM (n = 8 each). *P < 0.01 versus sham-operated mice of each genotype.