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. 2013 Nov 14;170(7):1396–1409. doi: 10.1111/bph.12346

Figure 2.

Figure 2

PDE5 inhibition attenuated cardiac hypertrophy and improved function in failing hearts. (A) to (E) show that sildenafil attenuated cardiac hypertrophy and dysfunction in rats induced by isoprenaline (Iso). (A) and (B) HE staining of rat hearts and cardiomyocyte cross-sectional diameter (μm). Scale bar: 100 μm. (C) Ratio of heart weight to body weight. *P < 0.05 versus saline. #P < 0.05 versus Iso. (D) and (E) Echocardiography parameters in isoprenaline rats and isoprenaline rats with sildenafil treatment. EF: ejection fraction, FS: fractional shortening. *P < 0.05 versus saline. #P < 0.05 versus isoprenaline. (F) to (H) show sildenafil attenuated cardiac hypertrophy and dysfunction induced by transverse aortic constriction transverse aortic constriction (TAC) in mice. (F) and (G) HE staining of mice hearts and cardiomyocyte cross-sectional diameter (μm). Scale bar, 100 μm. (H) Heart/body weight ratios of TAC mice. *P < 0.05 versus sham. #P < 0.05 versus TAC.