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Sildenafil (Sil) treatment in failing hearts restores SR calcium-handling proteins and phosphorylation. Western blots of SERCA2, total PLB (PLB) and phosphorylated PLB (P-PLB) expression in isoprenaline( Iso)-induced rats (A, B) and in TAC mice (C, D) *P < 0.05 versus saline or sham. #P < 0.05 versus Iso or TAC. Results shown are mean ± SEM; n = 3.
