Table 3.
Haemodynamic parameters in isoprenaline-treated rats (Iso) and isoprenaline-treated rats with the PDE5 inhibitor sildenafil (Iso + Sil)
| Control | Iso | Iso + Sil | |
|---|---|---|---|
| N | 6 | 5 | 6 |
| HR (bpm) | 213 ± 13.6 | 209 ± 17.7 | 203 ± 15.8 |
| PES (mmHg) | 143.6 ± 10.6 | 139.9 ± 50.1 | 147.7 ± 48.9 |
| PED (mmHg) | 7.6 ± 1.7 | 10.9 ± 4.1 | 8.9 ± 3.9 |
| dP/dtmax (mmHg·s−1) | 5291 ± 626 | 4047 ± 991* | 5123 ± 761# |
| dP/dtmin (mmHg·s−1) | –6915 ± 1251 | –4959 ± 1087* | –6411.3 ± 1122 # |
Data are mean ± SD.
*
P < 0.05 versus control.
#
P < 0.05 versus Iso.
dP/dtmax, maximal slope of systolic pressure increment; dP/dtmin, maximal slope of diastolic pressure decrement; HR, heart rate; PED, end-diastolic pressure; PES, end-systolic pressure.