Table 5.
Cardiac functional data of rats under control conditions (saline), after isoprenaline ( Iso) injection, and after isoprenaline injection plus sildenafil (Sil) and/or DT3
| Saline | DT3 (500μM·kg−1·day−1) | Iso | Iso + Sil | Iso + Sil + DT3 (100 μM·kg−1·day−1) | Iso + Sil + DT3 (500 μM·kg−1·day−1) | Iso + DT3 (500 μM·kg−1·day−1) | |
|---|---|---|---|---|---|---|---|
| N | 6 | 8 | 5 | 9 | 6 | 8 | 8 |
| HR (bpm) | 208 ± 10.3 | 211 ± 15.6 | 219 ± 8.9 | 201 ± 13.6 | 215 ± 15.1 | 220 ± 13.2 | 204.56 ± 11.6 |
| LVEF (%) | 79 ± 2.5 | 78 ± 2.8 | 65 ± 5.0* | 74.8 ± 1.4# | 71 ± 6.5 | 64 ± 4.5*& | 65.03 ± 3.52*& |
| LVFS (%) | 43 ± 3.0 | 44 ± 2.9 | 33 ± 3.3* | 39 ± 2.2# | 38 ± 5.8 | 32 ± 4.0*& | 30.14 ± 2.89*& |
| LVPWd (mm) | 2.05 ± 0.1 | 2.02 ± 0.15 | 2.17 ± 0.9 | 1.97 ± 0.09 | 1.94 ± 0.08 | 2.12 ± 0.08 | 2.4 ± 0.55 |
| LVPWs (mm) | 2.23± 0.5 | 2.4 ± 0.1 | 3 ± 0.25 * | 2.56 ± 0.25# | 2.7 ± 0.26 | 3.06 ± 0.15*& | 3.17 ± 0.15*& |
*
P < 0.05 versus saline.
#
P < 0.05 versus Iso.
&
P < 0.05 versus Iso + Sil.
HR, heart rate; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVPWd and LVPWs, posterior wall thickness at diastole and systole, respectively.