Plasmin increases cyclin D1 expression. (A, B) Levels of cyclin D1 protein (%control) in ASM cells incubated with plasmin (5 mU·mL−1) for 3–48 h. (C) Levels of cyclin D1 mRNA (%control) following incubation with plasminogen (Plg, 5 μg mL−1), plasmin (Plm, 5 mU·mL−1), bFGF (300 pM) or TGF-β (100 pM) for 24 h. *P < 0.05, ** < 0.01 versus control (n = 4–5).