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Urokinase and annexin A2 regulate plasminogen-stimulated ASM cell proliferation. The proposed effects of soluble, extracellular uPA and annexin A2 (as a component of AIIt) on plasminogen-stimulated cell proliferation occurs in the fluid phase and involves plasmin-activated signalling. The latter potentially involves MMP and annexin A2 activation in the fluid phase and subsequent receptor (i.e. EGF receptor and TLR4) activation.
