Table 1. Demographics, Questionnaires, and Neurocognitive Results: Means and Standard Errors.
Medical Comorbidities Questionnaire (MCQ)- Total score,higher score indicates more medical co-morbidities; Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue)-Total score, higher score equals better QOL; Patient Health Questionnaire-9 (PHQ9) total score, higher score indicates more severe depression symptoms ; Beck Anxiety Inventory (BAI)- total score higher score indicates more severe anxiety symptoms; Rey Auditory Verbal Learning Test (RAVLT) raw scores, higher score indicates better verbal memory; Stroop raw score (Seconds to completion) higher is worse performance; Digit Symbol raw score- higher score is better performance; Digit span raw score-higher score is better performance; FACT- Functional Assessment of Cancer Therapy- Cognition (FACT-Cog) -cognitive subscale scores, QOL- higher score equals higher quality of life, Perceived cognitive abilities- higher score indicates a higher perception of abilities, Perceived cognitive symptoms- higher score indicates fewer adverse symptoms,
| Demographics | Treatment | Control | Total | Significance | ||
|---|---|---|---|---|---|---|
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| N | 12 | 16 | 28 | -- | ||
| Age | 60.5 (2.3) | 57.8 (3.8) | 58.9 (2.4) | NS | ||
| Education | 17.8 (0.5) | 16.5 (0.5) | 17.1 (0.4) | NS | ||
| MCQ | 13.9 (SD = 12.6) | 17.3 (SD = 11.4) | 15.5 (SD = 12.0) | NS | ||
| Sex | F = 11; M = 1 | F = 15; M = 1 | F = 26; M = 2 | NS | ||
| Years Since Treatment | 5.04 (1.2) | 4.64 (1.4) | 4.84 (1.0) | NS | ||
| Treatment Modalities | ||||||
| Chemotherapy | 12 | 13 | 25 | NS | ||
| Radiation | 5 | 8 | 13 | NS | ||
| Surgery | 8 | 14 | 22 | NS | ||
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| Measures | Pre | Post | Pre | Post | ||
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| Quality of Life Measures | ||||||
| FACT-Cog Cognitive Quality of Life | 8.2 (1.4) | 9.9 (1.4) | 8.7 (1.1) | 9.8 (1.2) | -- | p < 0.01 |
| FACT-Cog Perceived Cognitive Abilities | 15.8 (2.4) | 20.1(2.3) | 16.2 (2.0) | 17.1 (1.9) | -- | p < 0.01 |
| FACT-Cog Perceived Cognitive Impairment | 35.7 (6.3) | 51.0 (5.7) | 37.7 (5.1) | 42.9 (4.7) | -- | p < 0.01 |
| Mood and Symptom Measures | ||||||
| FACIT-Fatigue | 17.4 (2.7) | 13.5 (1.9) | 20.9 (2.8) | 17.2 (2.0) | -- | NS |
| PHQ9 | 5.7 (1.6) | 4.5 (1.2) | 7.2 (1.7) | 6.6 (1.3) | -- | NS |
| BAI | 6.2 (1.9) | 4.3 (1.4) | 8.6 (2.0) | 7.9 (1.5) | -- | NS |
| Neurocognitive Tests | ||||||
| RAVLT- Total trials 1-5 | 29.8 (1.7) | 29.4 (1.4) | 27.4 (1.5) | 27.9 (1.2) | -- | NS |
| RAVLT Delay | 10.4 (0.7) | 10.7 (0.7) | 9.6 (0.6) | 9.3 (0.6) | -- | NS |
| Stroop Interference Trial | 61.1 (4.3) | 54.0 (4.8) | 57.8 (3.7) | 55.9 (4.3) | -- | NS |
| Digit Symbol | 69.1(4.3) | 72.0 (3.9) | 70.9 (3.7) | 70.9 (3.4) | -- | NS |
| Digit Span Forward | 10.6 (0.5) | 11.4 (0.6) | 9.4 (0.5) | 9.6 (0.5) | -- | NS |
| Digit Span Backward | 7.5 (0.5) | 9.8 (0.6) | 6.7 (0.5) | 7.4 (0.5) | -- | p < 0.01 |
| Digit Span Total | 18.1(0.9) | 21.3 (1.1) | 16.1 (0.5) | 17.0 (1.0) | -- | p < 0.01 |
Significant results are indicated in BOLD - and occurred only in the treatment group