Figure 2.

Trajectory analysis for a simulation started from a Cluster-1 conformation. (a) Root-mean-squared deviation from starting structures for EphA2 and SHIP2 SAM domains as well as for the complex; (b) angle between the fifth helix of the two domains (different configurations sampled are indicated by color bars with reference to Fig. 1c); and (c) buried solvent-accessible surface area at the protein-protein interface. To see this figure in color, go online.