Figure 1.

Changes in bendability with temperature. (Left panel) Cartoon of a two-dimensional representation of the potential range of chain configurations occupied by a DNA molecule whose trajectory is dependent on sequence-dependent bending anisotropy. When the temperature is raised, the occurrence of transient bubbles (red dots) locally increases both bending flexibility and isotropy leading to an increase in the potential range of configurations. Adapted from Satchwell et al. (12). To see this figure in color, go online.