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PP2A inhibition acutely improves hepatic insulin signaling in fat-fed rats. I.p.-injection of LB1 resulted in an augmented insulin-stimulated phosphorylation (Ser474) and activation of hepatic Akt2 (Ser474) (a) and phosphorylation (Ser256) and inactivation of FoxO1 (b) in vivo. Fold change is relative to insulin-stimulated, vehicle-injected rats. Data are averages of western blot quantifications ±SEM. * P<0.05.
