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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Behav Brain Res. 2013 Oct 5;257:10.1016/j.bbr.2013.09.050. doi: 10.1016/j.bbr.2013.09.050

Figure 4.

Figure 4

The induction of Asenapine (ASE) sensitization and its expression assessed at 3 time intervals. Number of avoidance responses made by the rats on the final training (predrug) day, five drug test days (a), and the first drug-free retraining day (b). Rats were injected ASE (0.2 mg/kg, sc, −30 min) or vehicle (VEH) and tested for avoidance responses for 5 daily sessions. D10, D20, or D40 groups (n = 8-9/group) received either 7, 17, or 37 days of resting, and were then retrained in the conditioned avoidance response boxes for two sessions. (c) The mean group avoidance percentage calculated by dividing the mean group number of avoidance in the ASE group by that in its corresponding VEH group. (d, e) ASE sensitization tested at 10-, 20- and 40-day intervals. All groups were injected with ASE (0.1 mg/kg, sc) and avoidance responses were measured 30 min later. All data are expressed as mean + SEM. ***p < 0.001, **p < 0.01 for comparison to the respective VEH group.