Table 2.

Cancer-associated mutations of PP2A A subunits.

Subunit	Mutation name	Alternations	Consequence	Cancer type	References
PR65α	E64D E64G R418W	Point mutation	Deficiency in binding to B′α1 Deficiency in binding to B/C subunits	Breast Lung Skin	[15, 17, 61]
	Δ171-589	Deletion		Breast
PR65β	G8R P65S G90D L101P L101P/V448A K343E V448A D504G V545A	Missense	Dysregulation of RalA GTPase, leading to impaired binding capacity to B/C subunits	Lung Breast Colon	[12, 15, 43]
	ΔE344-E388	In-frame deletion			[12, 15, 43]