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. Author manuscript; available in PMC: 2013 Nov 24.
Published in final edited form as: Sci Transl Med. 2013 Jun 12;5(189):10.1126/scitranslmed.3005615. doi: 10.1126/scitranslmed.3005615

Fig. 3. Aβ concentrations and selected kinetic parameters.

Fig. 3

Parameters for Aβ production rate (A), fractional turnover rate (FTR) (B), and baseline CSF concentrations (C) are shown for each group by mutation status and without (PIB−) or with (PIB+) evidence of amyloid deposition. Each parameter was measured for Aβ38 (1st column), Aβ40 (2nd column), Aβ42 (3rd column) and the Aβ42: Aβ40 ratio (4th column), and compared by mutation status and amyloid deposition. Error bars indicate 95% confidence intervals (CI). Mutation status compared when amyloid deposition did not affect magnitude or significance. * P<0.05, ** P<0.01, *** P<0.001, p-values by ANOVA based on mutation status with PIB MCBP score as a covariate. Non-carriers, blue circles; mutation carriers PIB− (MC PIB−), green squares; mutation carriers PIB+ (MC PIB+), red triangles. Each point represents one participant.