Skip to main content
. Author manuscript; available in PMC: 2013 Nov 24.
Published in final edited form as: Sci Transl Med. 2013 Jun 12;5(189):10.1126/scitranslmed.3005615. doi: 10.1126/scitranslmed.3005615

Table 1.

Complete list of model parameters.

Parameter Non-carriers Mutation-carrier PIB− Mutation-carrier PIB+
kAPP 1,171 ± 227 1,304 ± 602 1,291 ± 324
kC99 0.666 ± 0.112 0.553 ± 0.083 0.695 ± 0.096
kAβ38 0.062 ± 0.010 0.055 ± 0.016 0.059 ± 0.008
kAβ40 0.238 ± 0.041 0.187 ± 0.023 0.247 ± 0.037
kAβ42 0.033 ± 0.006 0.034 ± 0.007 0.041 ± 0.006
vC99 0.333 ± 0.056 0.276 ± 0.041 0.347 ± 0.048
v38 0.069 ± 0.023 0.075 ± 0.027 0.054 ± 0.015
v40 0.074 ± 0.023 0.082 ± 0.037 0.050 ± 0.013
v42 0.064 ± 0.014 0.126 ± 0.072 0.120 ± 0.037
kCSF 0.074 ± 0.023 0.082 ± 0.037 0.050 ± 0.013
kex38 0.020 ± 0.038 0.000 ± 0.000 0.000 ± 0.000
kex40 0.016 ± 0.032 0.009 ± 0.018 0.000 ± 0.000
kex42 0.010 ± 0.021 0.041 ± 0.045 0.120 ± 0.107
kret 0.1 0.1 0.1
kdelay 0.666 ± 0.112 0.553 ± 0.083 0.695 ± 0.096
SF38 0.937 ± 0.066 0.885 ± 0.063 0.979 ± 0.092
SF40 0.933 ± 0.043 0.916 ± 0.078 0.977 ± 0.130
SF42 0.972 ± 0.102 0.879 ± 0.021 0.912 ± 0.151

aAll units are first order rate constants with units h−1, except for scaling factors (SF), which are unitless, and kAPP, which is a zero order rate constant for APP production (ng/h). Note that kC99 = kdelay; kAβ38+kAβ40+kAβ42 = vC99; and kAβ38+kAβ40+kAβ42+vC99 = kdelay. Values are mean ± SD