Table 2.

Gene–gene interaction for BMI between the KLF9 and GDF8 loci

Independent variables in the regression model				Associations with BMI in the regression model
rsID	Cytoband	Gene	A1/A2a	GWAS		Replication studyc		Combined
				Beta (SE)b	P	Beta (SE)b	P	Beta (SE)b	P
rs11142387d	9q21	KLF9	C/A	0.088 (0.012)	8.3×10−14	0.117 (0.027)	1.7×10−5	0.093 (0.011)	1.1×10−17
rs13034723d	2q32	GDF8	A/G	−0.065 (0.015)	2.8×10−5	−0.068 (0.029)	0.018	−0.065 (0.014)	1.5×10−6
rs11142387 × rs13034723e	-	-	-	0.064 (0.013)	1.7×10−6	0.073 (0.025)	0.0031	0.066 (0.012)	2.0×10−8

^aBased on forward strand and NCBI Build 36.

^bEffect size of allele 1 on the normalized BMI (mean = 0, standard deviation = 1).

^cConsisted of replication sets 1 and 2 (Supplementary Fig. 1).

^dAllele dosage of allele 1 was used as an independent variable.

^eProduct of allele dosages of alleles 1 of rs11142387 and rs13034723 was used as an independent variable.

BMI, body mass index; GWAS, Genome-wide association study; SE, standard error.