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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Adv Healthc Mater. 2012 Sep 26;2(3):10.1002/adhm.201200257. doi: 10.1002/adhm.201200257

Figure 8.

Figure 8

Comparisons between E10- and E3-terminated polymers for DNA delivery. E10-polymers show significant differences in DNA transfection ability compared to other end-caps like E3. (A–C) For moderately to highly effective polymers, the E3 end-cap was much more effective; for otherwise very ineffective polymers, the E10 end-cap was more- effective. Significance was calculated with a paired t-test with a Bonferroni correction to account for 15 different comparisons (*p<0.05, **p<0.01). (D) By microscopy, this difference in GFP DNA delivery was also striking. (E) E10-polymers like 4510, 1.1:1, bound both DNA and siRNA efficiently in buffer alone (PBS) but show different profiles upon addition of glutathione (GSH). Numbers above lanes refer to polymer-to-nucleic acid w/w ratio.