Table 1.
Comparison of exosome components and cofactors in yeast and human cells
| Nucleolus |
Nucleoplasm |
Cytoplasm |
||||
|---|---|---|---|---|---|---|
| Yeast | Human | Yeast | Human | Yeast | Human | |
|
Nuclease | ||||||
|
EXO (RNase II/R) |
Rrp44 (Dis3) |
– |
Rrp44 (Dis3) |
DIS3 |
Rrp44 (Dis3) |
DIS3/DIS3L1 DIS3L2 |
|
ENDO (PIN, inactive) |
Rrp44 (Dis3) |
– |
Rrp44 (Dis3) |
DIS3 |
Rrp44 (Dis3) |
DIS3/DIS3L1 DIS3L2 |
|
EXO (RNase D) |
Rrp6 |
hRRP6 |
Rrp6 |
hRRP6 |
– |
hRRP6 |
|
Poly(A) polymerase | ||||||
|
Non-canonical |
Trf4 (Pap2) [TRAMP4] |
hTRF4-2 [TRAMP] |
Trf4 (Pap2) [TRAMP4] |
– |
– |
– |
|
Non-canonical |
Trf5 [TRAMP5] |
hTRF4-1 [?] |
Trf5 [TRAMP5] |
hTRF4-1 [?] |
– |
– |
|
RNA helicase | ||||||
|
DExH |
Mtr4 [TRAMP] |
hMTR4 (SKIV2L2) [TRAMP] |
Mtr4 [TRAMP] |
hMTR4 (SKIV2L2) [NEXT] hSKI2 (SKIV2L) [SKI] |
Ski2 [SKI] |
hSKI2 (SKIV2L) [SKI] |
|
Other |
Sen1 [Nrd1–Nab3–Sen1] |
Senataxin [?] |
Sen1 [Nrd1–Nab3–Sen1] |
Senataxin [?] |
– |
Senataxin [?] |
|
RNA-binding | ||||||
|
Zn-knuckle |
Air1 [TRAMP] Air2 [TRAMP] |
ZCCHC7 [TRAMP] ZFC3H1 [?] ZC3H18 [?] ARS2 [?] |
Air1 [TRAMP] Air2 [TRAMP] |
ZCCHC8 [NEXT] ZFC3H1 [?] ZC3H18 [?] ARS2 [?] |
– |
– |
|
Sas10_Utp3 |
Rrp47 (Lrp1) |
C1D |
Rrp47 (Lrp1) |
C1D |
– |
– |
|
Other |
– |
– |
– |
RBM7 [NEXT] |
– |
– |
|
Other |
Mpp6 |
hMPP6 |
Mpp6 |
hMPP6 |
– |
– |
|
RRM |
Nrd1 [Nrd1–Nab3–Sen1] |
– |
Nrd1 [Nrd1–Nab3–Sen1] |
– |
– |
– |
|
RRM |
Nab3 [Nrd1–Nab3–Sen1] |
– |
Nab3 [Nrd1–Nab3–Sen1] |
– |
– |
– |
|
Other | ||||||
|
TPR |
– |
– |
– |
hSKI3 [SKI] |
Ski3 [SKI] |
hSKI3 [SKI] |
|
GTPase |
– |
HBS1L [?] |
– |
HBS1L [?] |
Ski7 |
HBS1L [?] |
| WD-repeat | Ski8 [?] | hSKI8 (WDR61) [?] | Ski8 [?] | hSKI8 (WDR61) [SKI] | Ski8 [SKI] | hSKI8 (WDR61) [SKI] |
Alternative names are given in brackets. Complexes are indicated in square brackets, where known.