Table 3.

Regions of Activation within the Placebo Condition for the Manipulation Compared to Maintenance Contrast (Manip vs Maint), and the Low-Load Manipulation Compared to Low-Load Maintenance Contrast (Low Manip vs Low Maint)

Region activated	X a	Y a	Z **	Z-score
Manipulation vs maintenance
Right dorsolateral prefrontal	48	4	28	4.44**
Left dorsolateral prefrontal	−42	8	28	4.25**
Right ventrolateral prefrontal	40	18	10	4.30**
Left ventrolateral prefrontal	−34	28	4	4.00**
Right parietal	42	−48	38	4.82**
Left parietal	−44	−42	38	4.76**
Anterior cingulate gyrus	−4	22	46	3.95**
Globus pallidus	16	−8	0	3.90**
Caudate nucleus	32	20	−8	3.39**
Putamen	−16	−12	10	3.29**
Thalamus	−8	4	8	3.26**
Maintenance vs manipulation
Left temporal	−50	−28	18	4.07
High load vs low load
Right dorsolateral prefrontal	50	24	32	3.87**
Left dorsolateral prefrontal	−36	6	34	5.28**
Right parietal	34	−78	40	4.25**
Left parietal	−36	−74	34	3.78**
Anterior cingulate gyrus	−14	18	52	4.71**
Thalamus	8	−4	0	4.11**

^aX, Y, and Z are coordinates in a standard stereotactic space in which positive values refer to regions right of (X), anterior to (Y), and superior to (Z) the anterior commissure.

^**p<0.05 (FDR).