Table 4.

Regions of Activation within the Combined Higher and Lower Dose Ketamine Conditions for the Manipulation Compared to Maintenance Contrast (Manip vs Maint), and the Low-Load Manipulation Compared to Low-Load Maintenance Contrast (Low Manip vs Low Maint)

Regions activated	X a	Y a	Z a	Z-score
Manipulation vs maintenance
Right dorsolateral prefrontal	44	16	36	4.61**
Left dorsolateral prefrontal	−44	6	34	4.46**
Right ventrolateral prefrontal	46	22	18	3.84**
Left ventrolateral prefrontal	−34	28	−6	3.90**
Right parietal	46	−50	42	4.11**
Left parietal	−46	−44	38	3.99**
Anterior cingulate gyrus	−4	18	46	3.97**
Caudate nucleus	14	−16	0	4.25**
Thalamus	12	28	12	2.67**
High load vs low load
Right dorsolateral prefrontal	46	26	30	2.95
Left dorsolateral prefrontal	−24	4	48	3.9
Right parietal	26	−58	44	2.94
Left parietal	−28	−54	26	2.92
Anterior cingulate gyrus	−10	22	38	3.94

^aX, Y, and Z are coordinates in a standard stereotactic space in which positive values refer to regions right of (X), anterior to (Y), and superior to (Z) the anterior commissure.

^**p<0.05 (FDR).