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. Author manuscript; available in PMC: 2014 Oct 21.
Published in final edited form as: Chem Res Toxicol. 2013 Oct 8;26(10):10.1021/tx400293s. doi: 10.1021/tx400293s

Figure 7. Suppression of ICL formation by increasing buffer molarity.

Figure 7

Reaction mixtures contained 10 mM GSH, MOPS buffer (pH 7.0), 2 μg DNA, and 0-200 μM Cr(VI) and were incubated for 3 hr at 37°C. Data are means±SD (n=3, ***-p<0.001). Where not seen, error bars are smaller than data symbols. (A) ICL formation in Cr(VI)-GSH reactions containing 25 or 50 mM MOPS. (B) Reduction of Cr(VI) by 10 mM GSH in the presence of 25 and 50 mM MOPS (pH 7.0).