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. 2013 Nov 25;3:3325. doi: 10.1038/srep03325

Figure 4. Single administration study with novel RNAi platforms against RPN2 gene in vivo and with an endocytosis assay in vitro.

Figure 4

The effects of transfection on the expression of RPN2-mRNA 24 h after the inhaled administration of RNAi therapeutic agents with (a) or without delivery reagents (b). Measurements of human RPN2 expression levels by real-time RT-PCR. Data represent the means ± SD (n = 4). *, P < 0.05 versus control siRNA group. (c) Endocytosis assay for naked RNAi therapeutic agents. Naked PnkRNAs were incorporated into the A549-luc-C8 cell cytoplasm through endocytosis in the absence of delivery reagents. The scale bars indicate 10 μm.